USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: Q04760 USC-OGP 2-DE database:  Q04760 Q04760 General information about the entry View entry in simple text format Entry name LGUL_HUMAN Primary accession number Q04760 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Lactoylglutathione lyase; EC=4.4.1.5; AltName: Full=Aldoketomutase; AltName: Full=Glyoxalase I; Short=Glx I; AltName: Full=Ketone-aldehyde mutase; AltName: Full=Methylglyoxalase; AltName: Full=S-D-lactoylglutathione methylglyoxal lyase;. Gene name Name=GLO1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0217: pI=4.87; Mw=21103 PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0559: pI=5.03; Mw=21553 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0832: pI=5.03; Mw=21803 Cross-references UniProtKB/Swiss-Prot Q04760; LGUL_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name LGUL_HUMAN Primary accession number Q04760 Secondary accession number(s) B2R6P7 B4DDV0 P78375 Q59EL0 Q5TZW3 Q96FC0 Q96J41 Sequence was last modified on  March 6, 2007 (version 4) Annotations were last modified on  March 15, 2017 (version 180) Name and origin of the protein Description RecName: Full=Lactoylglutathione lyase; EC=4.4.1.5; AltName: Full=Aldoketomutase; AltName: Full=Glyoxalase I; Short=Glx I; AltName: Full=Ketone-aldehyde mutase; AltName: Full=Methylglyoxalase; AltName: Full=S-D-lactoylglutathione methylglyoxal lyase; Gene name Name=GLO1 Encoded on Name=GLO1 Keywords 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Disulfide bond; Glutathionylation; Lyase; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Zinc. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D13315; BAA02572.1; -; mRNA EMBL L07837; AAA52565.1; -; mRNA EMBL S83285; AAB49495.1; -; mRNA EMBL AF146651; AAD38008.1; -; Genomic_DNA EMBL AB209801; BAD93038.1; ALT_INIT; mRNA EMBL AK293345; BAG56861.1; -; mRNA EMBL AK312662; BAG35544.1; -; mRNA EMBL BT019987; AAV38790.1; -; mRNA EMBL BT019988; AAV38791.1; -; mRNA EMBL AL391415; CAI21586.1; -; Genomic_DNA EMBL BC001741; AAH01741.1; -; mRNA EMBL BC011365; AAH11365.1; -; mRNA EMBL BC015934; AAH15934.1; -; mRNA CCDS CCDS4837.1; -. [Q04760-1]; . PIR A46714; A46714; . PIR S63603; S63603; . RefSeq NP_006699.2; NM_006708.2. [Q04760-1]; . UniGene Hs.268849; -; . PDB 1BH5; X-ray; 2.20 A; A/B/C/D=2-184 PDB 1FRO; X-ray; 2.20 A; A/B/C/D=2-184 PDB 1QIN; X-ray; 2.00 A; A/B=2-184 PDB 1QIP; X-ray; 1.72 A; A/B/C/D=2-184 PDB 3VW9; X-ray; 1.47 A; A/B=1-184 PDB 3W0T; X-ray; 1.35 A; A/B/C/D=1-184 PDB 3W0U; X-ray; 1.70 A; A/B=1-184 PDBsum 1BH5; -; . PDBsum 1FRO; -; . PDBsum 1QIN; -; . PDBsum 1QIP; -; . PDBsum 3VW9; -; . PDBsum 3W0T; -; . PDBsum 3W0U; -; . ProteinModelPortal Q04760; -; . SMR Q04760; -; . BioGrid 109001; 38; . IntAct Q04760; 4; . STRING 9606.ENSP00000362463; -; . BindingDB Q04760; -; . ChEMBL CHEMBL2424; -; . DrugBank DB03345; Beta-Mercaptoethanol; . DrugBank DB00143; Glutathione; . DrugBank DB00328; Indomethacin; . DrugBank DB03330; S-(N-Hydroxy-N-Iodophenylcarbamoyl)Glutathione; . DrugBank DB03602; S-Benzyl-Glutathione; . DrugBank DB04132; S-Hexylglutathione; . DrugBank DB03130; S-P-Nitrobenzyloxycarbonylglutathione; . iPTMnet Q04760; -; . PhosphoSitePlus Q04760; -; . SwissPalm Q04760; -; . BioMuta GLO1; -; . DMDM 134039205; -; . OGP Q04760; -; . REPRODUCTION-2DPAGE IPI00220766; -; . REPRODUCTION-2DPAGE Q04760; -; . EPD Q04760; -; . PaxDb Q04760; -; . PeptideAtlas Q04760; -; . PRIDE Q04760; -; . DNASU 2739; -; . Ensembl ENST00000373365; ENSP00000362463; ENSG00000124767. [Q04760-1]; . GeneID 2739; -; . KEGG hsa:2739; -; . CTD 2739; -; . DisGeNET 2739; -; . GeneCards GLO1; -; . HGNC HGNC:4323; GLO1; . HPA CAB040541; -; . HPA CAB040542; -; . HPA HPA059791; -; . MIM 138750; gene; . neXtProt NX_Q04760; -; . OpenTargets ENSG00000124767; -; . PharmGKB PA28724; -; . eggNOG ENOG410IU7X; Eukaryota; . eggNOG ENOG4111FDV; LUCA; . GeneTree ENSGT00390000009312; -; . HOVERGEN HBG025852; -; . InParanoid Q04760; -; . KO K01759; -; . OMA WMKSIPG; -; . OrthoDB EOG091G0GMY; -; . PhylomeDB Q04760; -; . TreeFam TF105011; -; . BRENDA 4.4.1.5; 2681; . Reactome R-HSA-70268; Pyruvate metabolism; . SABIO-RK Q04760; -; . UniPathway UPA00619; UER00675; . ChiTaRS GLO1; human; . EvolutionaryTrace Q04760; -; . GeneWiki GLO1; -; . GeneWiki Lactoylglutathione_lyase; -; . GenomeRNAi 2739; -; . PRO PR:Q04760; -; . Proteomes UP000005640; Chromosome 6; . Bgee ENSG00000124767; -; . CleanEx HS_GLO1; -; . ExpressionAtlas Q04760; baseline and differential; . Genevisible Q04760; HS; . GO GO:0005737; C:cytoplasm; TAS:UniProtKB; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005634; C:nucleus; IDA:HPA; . GO GO:0005886; C:plasma membrane; IDA:HPA; . GO GO:0004462; F:lactoylglutathione lyase activity; IDA:UniProtKB; . GO GO:0008270; F:zinc ion binding; IDA:UniProtKB; . GO GO:0005975; P:carbohydrate metabolic process; NAS:ProtInc; . GO GO:0006749; P:glutathione metabolic process; IEA:Ensembl; . GO GO:0009438; P:methylglyoxal metabolic process; IEA:Ensembl; . GO GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB; . GO GO:0030316; P:osteoclast differentiation; ISS:UniProtKB; . GO GO:0006090; P:pyruvate metabolic process; TAS:Reactome; . GO GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:Ensembl; . Gene3D 3.10.180.10; -; 1; . InterPro IPR029068; Glyas_Bleomycin-R_OHBP_Dase; . InterPro IPR004360; Glyas_Fos-R_dOase_dom; . InterPro IPR004361; Glyoxalase_1; . InterPro IPR018146; Glyoxalase_1_CS; . Pfam PF00903; Glyoxalase; 1; . SUPFAM SSF54593; SSF54593; 1; . TIGRFAMs TIGR00068; glyox_I; 1; . PROSITE PS00934; GLYOXALASE_I_1; 1; . PROSITE PS00935; GLYOXALASE_I_2; 1; . PROSITE PS51819; VOC; 1; .

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